Bills vs Cardinals Odds, Lines, and Spread

Kyler Murray running to field

Quarterback Kyler Murray and the Arizona Cardinals are 2.5-point home favorites over the Buffalo Bills on Sunday. Photo by Bob Kupbens/Icon Sportswire.
  • The Arizona Cardinals are 2.5-point home favorites over the Buffalo Bills on Sunday
  • Sunday betting record: 5-1; 3.84 units won
  • Arizona is just 1-2 against the spread as the home chalk; see below for our preview and pick

Two quarterbacks coming off monster games will go head-to-head at State Farm stadium as the 5-3 Arizona Cardinals play host to the 7-2 Buffalo Bills.

Bills QB Josh Allen passed for a season-high 415 yards and three touchdowns in a 44-34 victory over the Seattle Seahawks. Cards QB Kyler Murray threw for 283 yards and three TDS and also ran for 106 yards and a TD as Arizona lost 34-31 to the Miami Dolphins.

Even though the Cardinals are just 1-2 this season against the spread as a home favorite, they are holding forth as the 2.5-point chalk in this contest. They were a two-point pick in the opening line.

Bills vs Cardinals Odds – Week 10

Team Moneyline Spread Total
Buffalo Bills +128 +2.5 (-107) O 55.5 (-109)
Arizona Cardinals -148 -2.5 (-114) U 55.5 (-112)

Odds taken Nov. 14th at DraftKings

The weather certainly sets up for these two QBs to put on another show. The forecast is for 77 degrees, clear skies and 1 mph wind at Sunday’s 4:05 pm EST kickoff.

Allen vs Murray

Allen and Murray are part of the new breed among NFL QBs. They can move the ball with their arm and with their feet.

Murray leads all NFL QBs with 543 yards gained on the ground. His eight TD runs not only share the NFL lead among QBs, they are also tied for third overall in the NFL.

Allen might not be in Murray’s class but he’s still an elusive runner. He’s scrambled for 241 yards and five TDs. Allen is also tied for second in the league with three game-winning drives.

Murray is more dangerous at home. He shows a completion percentage of 70.15 and a passer rating of 101.3. He’s thrown for 299.7 yards per game. His road numbers in those categories are 65.1, 97.1 and 232.7.

Can Bills Stop Cardinals?

Arizona is the NFL’s #1 offense (422 yards per game) and the league’s #2 rushing offense (162.9 ypg). Neither of those numbers bode well for the Bills.

Overall, Buffalo rank as the NFL’s #18 defense (364 ypg). However, when it comes to stopping the run, the Bills drop to #21 in the league (125.9 ypg).

Arizona isn’t exactly stellar when it comes to preventing the run. The Cardinals are right behind the Bills in 22nd place (126.1 ypg). Arizona is the NFL’s eighth-best scoring defense, though, allowing just 22.5 points per game.

Injury Report

Cardinals starting right guard James Murray (hand) is out. Elsewhere on offense, Arizona running back Kenyan Drake (ankle) and tight end Maxx Williams (ankle) are questionable.

Defensively, both starting defensive ends – Leki Fotu (ankle) and Jordan Phillips (hamstring) – are out. Safety Budda Baker (groin) and cornerback Dre Kirkpatrick (thigh) are questionable.

For the Bills, free safety Micah Hyde (ankle) is questionable.

Trend Spotting

Buffalo’s third-down conversions will be an interesting subplot here. The Bills are third in the NFL at converting on third down (50.5%). The Arizona defense is #7 in the NFL at preventing third-down conversions (37.6%).

The Cardinals own an NFL-best point differential of +54. Despite their record, the Bills are just +9.

Arizona is the NFL’s #6 scoring offense (2.3 points per game). The Cards are just 2-2 straight up at home, while the Bills are 3-1 SU on the road.

The Cardinals are 5-0 ATS in their wins are 0-3 ATS in their losses. Overall, Buffalo is 4-5 ATS and the Bills are 1-1 ATS as an underdog.

When it comes to the total, the Bills are a solid over bet. They’ve gone 6-2-1. The Cardinals are just 2-6 but they’ve gone over two weeks in a row and both of these offenses are currently firing on all cylinders.

Pick: Over 55.5 points (-109), 1 unit.

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